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All other modalities were similarly held for the duration of the study

1 Although many upstream pathways lead to ferroptosis, they lead directly or indirectly to an imbalance of production and degradation of intracellular L-ROS, and eventually, ferroptosis

For epidermal keratin-forming cells, various extracellular stimuli (including UV light) can trigger signaling cascades associated with stress responses, the most important of which is the activation of mitogen-activated protein kinases (MAPKs)

It participates in methyl transfer and folate metabolism in the body, and promotes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate