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Release of IL-1 into the medium and cleavage of IL-1 in the cell lysates were decreased 50% by HNE compared to control, but NLRP3 and pro-IL-1 protein levels did not change (Fig

Similarly, deconjugation of SN-38-glucuronide by gut microflora, results in high concentrations of SN-38 locally, thereby causing severe delayed diarrhea (Kaneda et al., 1990)