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In addition, the fourth line of defense may be activated by the reaction and generation of free radicals, which in turn induces the production and transport of corresponding antioxidant enzymes to the effective site and causes the formation of catalase and superoxide dismutase [32, 35]

The DNA methylation patterns in PGR, FOXO1 (Forkhead Box O1) and inflammatory cytokines including IL-1, TNF- impact CL dysfunction leading to adverse pregnancy outcomes (196)