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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Kahn RS, Keefe RS

Obstruction of GSH synthesis affects the lipid membrane repair ability of GPX4, increases the rate of toxic lipid free radical and ROS accumulation, and promotes lipid peroxidation, resulting in ferroptosis [1, 2]