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In summary, based on the characteristic metabolic reprogramming of tumor cells, combination therapies that simultaneously target multiple metabolic pathways or synergize with other treatment modalities represent a systematic strategy to overcome the limitations of monotherapy, suppress tumor adaptation, and ultimately increase therapeutic efficacy

Bodineau C

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Both enzymes exhibit Michaelis-Menten type kinetics: k cat (H165N) = 0.021 0.001 s -1 , K M (H165N) = 164 13 mM, k cat (H165N, F279I) = 0.022 0.001 s -1 , K M (H165N, F279I) = 112 6 mM (mean S.D.)