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10.1097/00001756-199806220-00037 [DOI] [PubMed] [Google Scholar] Pujol R., Puel J

Natural plant components are complex, and future studies could focus on enhancing the activity of GPX4 and System X c - , inhibiting lipid peroxidation, and targeted regulation of the Nrf2 signaling pathway to reduce ferroptosis in the kidney

However, our earlier observations in the same species (unpublished data) did not reveal any significant differences in renal morphology or urinary protein excretion between SHR and WKY rats aged 416 weeks, except after 48 weeks of age when significant decreases in glomerular filtration rate and glomerular necrosis was evident in SHR