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Persistent oxidative stress in cancer

Still, one stands out called the salvage pathway because it is the most abundant in mammalian cells (the others are called the Preiss-Handler pathway, in which NAD+ is synthesized from nicotinic acid, and the de novo synthesis pathways, which starts from tryptophan)

Treatment with SOD mimetic (MnTMPyP) reduced the increased apoptosis sensitivity of CF cells, implicating superoxide-mediated oxidative stress (Rottner et al., 2011)