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It does not require a prescription in the traditional sense, but obtaining it through proper channels has become more difficult with the Category 2 classification

Future research should differentiate between symptomatic and asymptomatic infected individuals, select specific probiotics or their fermented products, utilize widely studied strains, standardize experimental protocols (including dosage, duration, and clinical endpoints), and assess the long-term effects of probiotic interventions

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When the intestinal barrier is compromised, increased antigen exposure activates these mast cells, creating a systemic inflammatory state that amplifies allergic reactivity everywhere