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Each histological subtype was already associated with a specific genetic and transcriptional signature: low-grade OSC generally comprising BRAF, KRAS, NRAS, Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2) mutations

Because collagen is part of the bone matrix, it may actually support healthy skeletal development when paired with a balanced diet

2020;19(5):e13146

Ovarian primordial follicular cells cannot regenerate, and aberrant death of these cells by chemotherapeutics leads to follicular dysfunction and oocyte atresia, which appears as POI 54