glutathione vs milk thistle & Thistle: Evidence & Safety – PlexusDx Glutathione NAC Milk Thistle Supplement

The Phase 2 SHAPE trial (NCT04831281) in Parkinsons disease dementia and dementia with Lewy bodies failed its primary endpoint in December 2023

The consequences for positive tests include: Disqualification from competition Loss of medals and records Suspension from sport (potentially years) Stripped sponsorships and endorsements Permanent career damage Trace amounts -- even levels far below what would provide any performance benefit -- can still trigger positive tests and sanctions

Many protocols use both: NAC to support internal production, and glutathione for immediate antioxidant presence

This method provides immediate bioavailability and higher blood levels than oral supplements, supporting energy production, nervous system function, and overall cellular health