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For example, a recent study that combined sequential cell fractionation (resolving six subcellular fractions) with phosphopeptide enrichment in cells and mice revealed the rapid relocalization of ribosomal subunits to the nucleolus in response to hypertonicity and muscle contraction, and alterations in the phosphorylation of ribosome assembly factors (Martinez-Val et al., 2021)

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Absence of COA documentation, unclear peptide sequence information, poor storage conditions, and vendors without established reputation all raise concerns

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