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These effects occur without elevating IGF-1 or affecting carbohydrate metabolism, differentiating it from full-length HGH in terms of safety and selectivity

Retatrutide (a triple GIP/GLP-1/glucagon receptor agonist), survodutide, mazdutide, and CagriSema represent the next generation of anti-obesity compounds that may offer even greater efficacy or better tolerability profiles

For type 2 diabetes management, the medication may be needed long-term as diabetes is a chronic condition requiring ongoing treatment, though some patients may be able to reduce or discontinue medication if significant weight loss and lifestyle modifications lead to remission of their diabetes

First, their proposed pathophysiology is described, and the possible diagnostic approaches along with recommended treatment options are demonstrated