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Hepatopatas graves, sobre todo las alcohlicas y cirrticas, ya que suelen presentar deficiencia de folatos y presentan una reduccin de las enzimas encargadas del metabolismo de la homocistena

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For instance, increased exhausted PD1+ natural killer (NK) cells have been reported in advanced stages of the disease, indicating a role for immune checkpoint dysregulation in disease progression and potential as a diagnostic target