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Injectables require additional supplies like syringes and Bacteriostatic Reconstitution Water (bac), which adds to the per-dose cost

HR-MDS: High-risk myelodysplastic syndromes HSCs: Hematopoietic stem cells HSPCs: Hematopoietic stem and progenitor cells ICT: Iron chelation therapy IDH1/IDH2: Isocitrate dehydrogenase 1/2 IL-1: Interleukin 1 beta IL-7/10: Interleukin-7/10 IOL: Iron overload IPSS-R: Revised international prognostic scoring system LEPR: Leptin receptor LR-MDS: Low-risk myelodysplastic syndromes MDS: Myelodysplastic syndromes Mfn2: Mitofusin MMP: Mitochondrial membrane potential MPO: Myeloperoxidase mROS: Mitochondrial ROS MSCs: Mesenchymal stromal cells Mt ETC: Mitochondrial electron transport chain MTCH2: Mitochondrial carrier homologue 2 mTOR: Mammalian target of rapamycin MYH11: Myosin heavy chain 11 NAC: N-acetylcysteine NAD + : Nicotinamide adenine dinucleotide NADPH: Nicotinamide adenine dinucleotide phosphate Nes: Nestin NFAT: Nuclear factor of activated T cells NF-B: Nuclear factor B NG2: Neural-glial antigen 2 NHD13: NUP98-HOXD13 NLRP3: NLR family pyrin domain containing 3 NO : Nitric oxide NOX: NADPH oxidase NOX1-5: NADPH oxidase 15 NOXA1: NADPH oxidase activator 1 NOXO1: NADPH oxidase organizer 1 Nrf2: Nuclear factor erythroid-2 related factor 2 O 2 : Oxygen O 2 : Superoxide anion radicals O 3 : Ozone

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Additionally, Amifostine must be administered in a narrow time window (1530 min) before each radiation dose because of its short half-life 16 , constraining its clinical use 17