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Acknowledgements The authors would like to thank Martin Balcerowicz and Marino Exposito-Rodriguez for their helpful comments on the manuscript

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Gutierrez-Aguilar M, Baines CP

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Peroxynitrite is a potent pro-oxidant (114) implicated as the causative agent of the cardiovascular endothelial dysfunction seen in T2DM (120)

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On the other hand, Nitric oxide (NO), as an inhibitory neurotransmitter, elicited hyperpolarization and relaxation of GI muscles (Grider et al., 1992

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