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Further studies have shown that under hypoxic conditions, up-regulation of HIF-1 leads to an increase in glucose transporter GLUT1 and GLUT3 in RA synovial tissue, thereby promoting glucose uptake and further enhancing the process of glycolysis by regulating the activities of hexokinase II, glyceraldehyde 3-phosphate dehydrogenase and mitochondrial cytochrome oxidase (126, 127)

In addition to its effect on child vitamin B-12 status, vitamin B-12 status in pregnancy may also have an effect on long-term child health

katsumadai can be used to treat asthma (Lee et al., 2010)

Except for weight gain and cushingoid facies (which were more frequent with prednisolone), other adverse effects were not different in the two groups