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In fact, a strong argument can be made that B12/MIC is a particularly versatile inhibitor of mTOR precisely because its various components each work to combat distinct catalysts of mTOR stimulation

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Additionally, Protein kinase C (PKC) pathway activation can induce insulin receptor substrate 1 (IRS-1) phosphorylation, inhibiting insulin signaling through downstream effectors such as Akt, phosphoinositide 3-kinase (PI3K), and glucose transporter 4 (GLUT-4) (Ritter et al., 2015