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Such protein-level analysis is crucial for understanding how genetic variations in LMNA affect the proteins function and structure, directly linking to the phenotypic diversity seen in laminopathies

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Through the utilization of IPA analysis, it became evident that LMNA (L35P), LMNA (R453W), and LMNA (A539V) variants were closely associated with various movement disorders, motor dysfunction, myocardial issues, and heart failure