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137 Importantly, the sustained synthesis of acetyl-CoA by ACLY and ACSS2 maintains a histone acetylation profile that promotes the transcription of pro-proliferative and growth genes even under nutrient-deplete conditions, thus allowing cancer cells to more rapidly induce these tumorigenic genetic programmes when microenvironmental conditions become favourable

What this study has made clear and this report must convey is the working of two powerful, related, but in a sense opposing processes: men and women are living longer lives than before