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Factors which influence barrier integrity including gut colonising microbes, genetic predisposition and environmental factors will also be explored

As well, the risk of bias was almost high in the included studies that might affect the quality of evidence

Non-glutathione disulfide substrates that employ monothiol mechanism (iii) should not be trapped as Grx(SSR) intermediates, which might explain the rather small number of verified non-glutathione disulfide substrates of glutaredoxins to date

Here, its cofactor is oxidized by one molecule of hydrogen peroxide and then regenerated by transferring the bound oxygen to a second molecule of substrate