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Among them, 243 samples underwent RAS testing, with only 45 patients having detectable mutations and a total of 21 mutations were detected in the NS5A gene, with no clinically significant resistance observed in the NS5B gene (Table 1)

Furthermore, although AD brain tissue frequently exhibits mitochondrial failure, new research has shown that peripheral mononuclear blood cells' mitochondrial activities have changed ( 3.2 Impaired electron transport chain function Alzheimer's disease is marked by decreased activity in several enzymatic complexes critical for ATP production, including the pyruvate dehydrogenase complex, -ketoglutarate dehydrogenase complex, complex I (NADH ubiquinone oxidoreductase), complex IV (cytochrome oxidase), and complex V (ATPase) (43, 44)

Even though all four volunteers were young and healthy, the degree of increase (1.6~14-fold) reflected individual variability in carnitine functions in blood and tissues

Activity of WP1130, a Deubiquitinase Inhibitor, against Acute Myelogenous Leukemia