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64 In a randomized, double-blind pilot study that assessed the impact of adding silymarin (420 mg/day) to standard chemotherapy on the clinical response of advanced malignancies following three cycles of cisplatin-based chemotherapy, a tendency of decreased metastasis rate in the chemotherapy plus silymarin group was reported though there was no significant variance in tumor size

If a deficiency is detected, your doctor may recommend vitamin B12 injections, which are often more effective than oral supplements due to metformins impact on stomach absorption

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