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It is well-known that the enhanced glycolytic pathways favor the induction of M polarization toward M1-type M (238), as well as the production of various inflammatory cytokines, including IFN- and TNF-

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Additionally, the analgesic effect of methadone is shorter than the pharmacologic half-life, leading to potential additive respiratory depression if the medication is dosed solely based on pain

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Horm Res (2000) 53(5):21520

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