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The PI3K/Akt signaling pathway mediates the high glucose-induced expression of extracellular matrix molecules in human retinal pigment epithelial cells

Increased mortality in patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure has been reported after treatment with pharmacologic amounts of growth hormone

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The targeted delivery of dexamethasone to GLP1R-positive cells prevented typical dexamethasone offtarget effects on glucose metabolism, bone density, and the hypothalamus-pituitary-adrenal axis activity (164)