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Activation of ER stress and apoptosis by -and -zearalenol in HCT116 cells, protective role of quercetin

The most classic example is immune checkpoint inhibitors (ICIs) (pembrolizumab and atezolizumab), which target the PD-1/PD-L1 axis and have shown clinical benefits by reactivating anti-tumor T-cell responses

1-carboxyphenyalanine is reported to be associated with poor response to metformin (Naja et al., 2023) and with lower microbiome diversity (Wilmanski et al., 2019), and previously shown to be most discriminating metabolite of insulin resistance (ahin et al., 2022)

Mechanistic studies indicate that curcumin reduces the levels of pro-inflammatory cytokines (IL-1, IL-6, IL-18, and TNF-) in intestinal tissues, thereby alleviating intestinal inflammation