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The permutation results suggest that the three-SNP model is the best fit for our data, though several SNPs may be good candidates for future studies

Glutamate dehydrogenase and glutamate production The evidence that glutamate may serve as a second messenger to amplify insulin secretion comes from identifying a gain-of-function mutation in the gene encoding glutamate dehydrogenase (GDH), an enzyme that catalyses conversion of -ketoglutarate to glutamate