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2 Treatment approaches related to TMAO The above content suggests that the majority of TMA is absorbed into the hepatic portal venous circulation via passive diffusion across the intestinal cell membrane and subsequently converted to TMAO by hepatic FMO3, and TMAO elimination can be achieved by targeting specific pathways, including inhibition of TMA precursor production, suppression of TMA production, and blocking the conversion of TMA to TMAO

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