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Am J Pathol 178:175186 Alnouti Y, Csanaky IL, Klaassen CD (2008) Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LCMS/MS

(PubMed) Brion LP, Bell EF, Raghuveer TS, Soghier L

A pre-activity dose (around 30-60 minutes prior) is theorized to increase blood flow to target areas during the activity, potentially enhancing delivery