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Microvascular pericytes are particularly important as they contribute to maintenance of the BBB, regulate cerebral blood flow, play a key role in generation of new blood vessels, aid microvessel stability, and clear waste from the brain [31]

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Ultimately, we advocate a rationale to improve the outcome of anti-MET therapies on the basis of thorough consideration of the entire spectrum of MET-mediated biological responses, which implicates adequate patient stratification, meaningful biomarkers and appropriate clinical end points