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It also showed beneficial impacts on glycemic and blood pressure control as well as lipid metabolism in hypertensive patients without serious adverse effects such as liver and kidney dysfunction [181]

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In particular, Nrf2 coordinates the expression of enzymes involved in the biosynthesis and recycling of glutathione (GSH), including glutamate-cysteine ligase catalytic and modifier subunits (GCLC and GCLM), glutathione synthetase (GSS), and the cystine/glutamate antiporter component SLC7A11

Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis