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188 However, contrary findings suggest that -ketoglutarate production activates mTORC1 signaling and sustains an immunosuppressive M2-like macrophage phenotype

Int J Obes (Lond) 44(1):178-85 2020 PMC7366782 Sewaybricker LE, Melhorn SJ, Papantoni A, Webb MF, Hua J, Roth CL, Carnell S, Schur EA

In contrast to both asthma and COPD [62], CF is a single gene disorder that arises from mutations in the cystic fibrosis conductance regulator (CFTR) gene [63]