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Fungal organisms, notably Candida albicans and Aspergillus fumigatus , reprogram mitochondrial respiration under oxidative stress conditions imposed by the host immune system ( Plasmodium falciparum and Trypanosoma cruzi , exploit mitochondrial remodeling to acquire nutrients and modulate redox balance (Rodrguez-Hernndez et al., 2020

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This imbalance interferes with the body's ability to detoxify the cellular microenvironment, fold proteins, replenish antioxidant levels, maintain healthy immune responses and even modulate apoptotic events