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PGH can occur as an autosomal disease, premature aging disorders such as progeria and pangeria, oxidative stress as a result of ultraviolet rays, pollution, emotional factors, or inflammatory causes, Vitamin B12 deficiency, decreased thyroid hormones, and minerals such as copper, iron, calcium, and zinc as well as drugs reducing melanogenesis.[2,5,6] The effects of -melanin-stimulating hormone (MSH) by binding to melanocortin 1 receptor (MC1-R) on normal human melanocytes are recognized as a key signal of cutaneous melanogenesis by the activation of downstream factors, microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein 1 (TRP-1), and TRP-2.[7] For treating PGH, various Vitamins and minerals such as biotin, calcium pantothenate, zinc, copper, and selenium are prescribed, however, the treatment outcomes are not satisfactory.[8] Herein, we present a case of a patient with PGH which was reversed with topical application of Greyverse solution constituting palmitoyl tetrapeptide-20 (PTP20), a biomimetic biopeptide of -MSH