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pmid:26865836 35

Functionally, high-TRIM37 induces non-transformed breast cells tumorigenic, and inhibition of TRIM37 action decreases tumor growth

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The pathophysiological mechanisms of depression are not refined, but many studies suggested that the impairment of intracerebral neurotransmission of 5-HT, NE, and DA is mainly accountable for the induction of depression ( Depression reduces the 5-HT neural action and the 5-HT1A autoreceptor sensitivity