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14,15,16 After activation of the nuclease character of IRE1, it excises an intron (a 26-nucleotide segment) from mRNA encoding a UPR-specific transcription factor called XBP1 (X-box binding protein 1) in metazoans, which transforms the unspliced XBP1 (XBP1u) to the spliced XBP1 (XBP1s)

Vet Hum Toxicol 23(Suppl 1):3942 da Silva RF, dos Borges CS, Villela ESP, Missassi G, Kiguti LR, Pupo AS, Barbosa Junior F, Anselmo-Franci JA, de Kempinas WG (2016) The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system

They share the same corrin ring structure with a central cobalt atom

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