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doi: 10.1080/09291016.2011.593847 19 BeaverLMKlichkoVIChowESKotwica-RolinskaJWilliamsonMOrrWCet al

Third, the primary EGFR-activating mutations in the two cell line pairs were different (E746-A750 for PC9/PC9ER cells, L858R for H3255/H1975 cells)

They are considered unsafe and even ineffective

This latter finding is of particular interest, as rather than simply modifying the PDHc, glutarate formed a fatty acid conjugate that binds to the lipoylated catalytic arm of PDHc