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He died in 2024 at 77, largely unknown in the West, his research sealed behind the iron curtain that kept it from the scientists who might have replicated or challenged it

However, replicating this model remains challenging due to its dependence on mutual trust, institutional continuity, and long-term policy support, which require extended periods of coordinated development to establish effectively

Additionally, leflunomide treatment decreased the levels of MMP-1, MMP-9, and cartilage oligomeric matrix protein (COMP) in the serum of patients with RA (290)

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