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Elevated expression of miR18a was confirmed by multiple probes in the array (Appendix Table S3)

Based on mRNA expression both sequences reduced expression to ~45% of the non-silencing control (nsSiRNA

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Vilchez D, Simic MS & Dillin A

DNAzymes have demonstrated well-tolerability in clinical trials targeting c-jun and EBV LMP1 proteins, because these molecules can cross the BBB following systemic injection, eliminating the need for direct brain injections 11