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Cancer 128 , 13331343 (2023)

Monitoring in this class centers on IGF-1, not GH directly , because IGF-1 is the durable, measurable signal of axis activity

About 40% of thyroid patients are deficient in vitamin B12, making it one of the most common and overlooked nutrient deficiencies in this population

Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses