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Design of acid-activated cell-penetrating peptides with nuclear localization capacity for anticancer drug delivery

Strengths: High bioavailability -- bypasses gut degradation entirely Community-reported dose range of 200-600 mg per injection, 2-3 times per week Cost-effective at scale ($0.03-0.15/mg from research vendors) Self-administered at home once reconstituted Limitations: Requires reconstitution and injection supplies (syringes, bacteriostatic water, alcohol swabs) Reconstituted solution must be refrigerated and used within 28 days Not suitable for needle-averse individuals Best for: Users who want the highest-bioavailability home-use option and are comfortable with injection protocols

409 In addition to genomic markers, functional indicators of autophagy flux, such as LC3 puncta, p62/SQSTM1 accumulation, and ATG expression, are under investigation as clinical biomarkers

J Chengdu Univ Trad Chin Med