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J., Friedman T

Third, cosmetic-study endpoints (subjective firmness scores, instrumental elasticity, photographic grading) are softer and more variable than the hard clinical endpoints used in drug trials

PLoS One 9:e101815

This was done in the presence of the CI-linked substrates pyruvate (5 mM), malate (2 mM) and in the absence of ADP (2.5 mM) followed by the addition of cytochrome c (10 M) to test for the integrity of the mitochondrial outer membrane (cytochrome c control efficiency)