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Pathogen-associated molecular patterns (PAMPs) include sugars/lipoproteins or nucleic acids [i.e., bacterial DNA as unmethylated repeats of dinucleotide CpG, double-stranded (ds) or single-stranded (ss) RNA] ( Since their original definition as DAMPs in 2003, the list of endogenous molecules are increased considerably ( Nucleotides and nucleosides, for long time considered simply electron-shuttling agents involved in supporting energy metabolism, are gaining interest together with the network of enzymes that control their synthesis and degradation

Albeit using different methodology, another group discovered aberrant resting state functional connectivity within the cingulo-opercular network and between, cingulo-opercular and cerebellar networks, and cerebellar and salience networks in bipolar patients compared to controls

I let you knowevery body is DIFFERENT Yes, some patients respond to cortisone better than others