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Young-onset and late-onset Parkinsons disease exhibit a different profile of fluid biomarkers and clinical features

Abnormal -synuclein aggregation forms Lewy bodies, contributing to cell apoptosis, mitochondrial dysfunction, and endoplasmic reticulum stress, which are hallmarks of PD 26

Persistent STAT3 activation can induce antiapoptotic proteins (e.g., Bcl-2 and Mcl-1) and angiogenic factors [e.g., vascular endothelial growth factor (VEGF)], forming a microenvironment conducive to tumor growth

I think one of the biggest access points weve got is this readily built national prevention network within Holland & Barrett, Dr