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It's formed when three amino acids (glycine, histidine, lysine) combine and then attach onto a copper particle

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The impaired gait and locomotor phenotype observed in RGS6 / mice suggest a more significant role for RGS6 in the cerebellum ( / mice indicated that RGS6 hinders the efficiency and kinetics of muscarinic receptor (M2R)-GIRK coupling and diminishes the amplitude of adenosine receptor (A1R)-GIRK signaling ( RGS4, a member of the R4 subfamily, exhibits high expression in the brain and the heart, forming complexes with various GPCRs and accelerating GIRK channel gating kinetics ( Xenopus oocytes decreases the baseline GIRK1/2 current and significantly enhances the proportion of agonist-induced K + conductance (Ulens et al., 2000)