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Conclusion: In a middle-aged cohort from the general population with no preexisting AF echocardiographic and biochemical markers of AtCM were not associated with CBI

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8385 Importantly, the LDL-C lowering achievable with ANGPTL3 inhibition occurs via a mechanism of action thatunlike most currently approved lipid-lowering therapies such as statins, ezetimibe, and proprotein PCSK9 inhibitorsis independent of the LDLR