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Interestingly, the crosstalk between OLs and neurons is of paramount relevance to prevent increased oxidative stress and ferroptosis in neurons, as OLs can deliver ferritin heavy chain to neurons to alleviate the oxidative stress burden and rescue neuronal death (55)

These include C-reactive proteins, IL-6, IL-8, adhesion molecules such as ICAM-1 and VCAM-1, and monocyte chemotactic protein-1 (MCP-1)

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Phase 2 data in type 2 diabetes showed CagriSema reduced HbA1c by 2.2 percentage points compared to 1.8 with semaglutide alone and 0.9 with cagrilintide alone, while achieving 15.6% weight loss versus 5.1% with semaglutide alone