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Liu W, Ma Y, He Y, Liu Y, Guo Z, He J, Han X, Hu Y, Li M, Jiang R, Wang S

10.3389/fphar.2022.953205 48 HelmickH.JainA.TerashiG.LiceagaA.BhuniaA

Acute Myeloid Leukemia Acute leukemia represents the predominant form of cancer among children, comprising 26% of total cancer diagnoses and 20% of cancer-related fatalities in the pediatric population

In recent years, breakthroughs have been made in targeted intervention strategies against GPx4, from early covalent inhibitors such as RSL3, to the emerging PROTAC degradation technology, to the combined application of multiple therapeutic modalities