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Although the substrate competition between Arg1 and iNOS, as well as the anti-inflammatory effects of -KG, show a certain degree of consistency across multiple models, branched-chain amino acid (BCAA) and tryptophan metabolism may exhibit divergent or even opposite trends in different disease contexts and tissue microenvironments ( Overall, macrophage polarization is more appropriately understood as the result of metabolic network remodeling, in which glucose metabolism, lipid metabolism, and amino acid metabolism do not operate in isolation, but instead form a highly coupled regulatory system at the levels of metabolic flux direction, signal transduction, and epigenetic regulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Rashidi-Nezhad A, Talebi S, Saebnouri H, Akrami SM, Reymond A

In vitro synergistic activities of fosfomycin in combination with other antimicrobial agents against carbapenem-resistant Escherichia coli harboring bla NDM-1 on the IncN2 plasmid and a study of the genomic characteristics of these pathogens

A , B HK-2 cells were treated with MCTR1 (100 nM) and LPS (1 ug/ml) for 8 h