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Description

isoform '1' encodes p16(INK4a), while isoform '4' encodes p14(ARF), a protein that is structurally unrelated to p16(INK4) but acts in cell cycle G1 control by stabilizing the tumor suppressor protein p53

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Yan X, et al

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Current mechanistic and pharmacodynamic understanding of melanocortin-4 receptor activation

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