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Medications and Glucose-6-Phosphate Dehydrogenase Deficiency An Evidence-Based Review Ilan Youngster Lidia Arcavi Renata Schechmaster Yulia Akayzen Hen Popliski Janna Shimonov Svetlana Beig Matitiahu Berkovitch Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme

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Neuronal glucose uptake is predominantly facilitated by GLUT3, although other transporters such as GLUT2 and GLUT4 may be involved in glucose uptake into neurons under specific physiological or pathophysiological conditions (183)